Directing Neuronal Networks back to Harmony
Our miRNA-targeting approach restores balance by guiding neural networks back to healthy function.
Conventional medicine typically targets individual symptoms rather than the disease as a whole
Yet many symptoms remain untreated. Even when traditional drugs have an effect, their impact often fades despite increasing doses, and side effects can be severe.
Our therapeutics focus on treating the cause of disease. MiRNAs regulate the function of other RNAs, which in turn influence how neurons fire. By focusing on miRNAs, our treatment addresses the disease at its origin. From there, its effect ripples throughout neuronal pathways, harmonizing and coordinating the firing of neurons to restore healthy function.
miRNAs
Our strategy is based on microRNAs (miRNAs). These tiny molecules influence other RNAs, regulating gene expression and helping coordinate the function of neuronal networks. Our therapeutic approach is to design chemically modified antisense oligonucleotides (ASOs) that inhibit the function of overactive miRNAs in neurological disease.
Antisense Oligonucleotides
Antisense Oligonucleotides, or ASOs, are synthetic strands of nucleotides designed to bind and inhibit specific RNA sequences. This technology offers the potential to correct genetic defects, regulate miRNA activity, and treat diseases at their molecular roots. By using ASOs, we can develop targeted, highly effective therapies that address the underlying causes of complex conditions.